Reserve concomitant prescribing of those medicine in patients for whom other therapy selections are inadequate. Restrict dosages and durations towards the minimum amount required. Keep an eye on closely for indications of respiratory despair and sedation.
fentanyl intranasal and diazepam equally raise sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom different therapy solutions are insufficient
fentanyl transdermal and diazepam equally maximize sedation. Keep away from or Use Alternate Drug. Limit use to individuals for whom different procedure solutions are insufficient
larotrectinib will boost the stage or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Robust or average CYP3A4 inhibitors may perhaps reduce level of diazepam elimination, thus increasing adverse reactions to diazepam.
cenobamate will increase the degree or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Carefully. Think about a dose reduction of CYP2C19 substrates, as clinically correct, when utilised concomitantly with cenobamate.
crizotinib raises amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Dose reduction may very well be desired for coadministered prescription drugs that happen to be predominantly metabolized by CYP3A.
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Just before making use of VALTOCO, tell your Health care company about your whole professional medical problems, together with in the event you:
dronedarone will enhance the degree or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Simply because diazepam and its metabolites may be check here present in human breast milk for extended periods of time immediately after acute use, individuals need to be encouraged never to breastfeed for an appropriate period of time right after getting treatment method
Steer clear of or substitute A different drug for these remedies when probable. Appraise for loss of therapeutic result if medication must be coadministered. Regulate dose according to prescribing information if required.
etravirine will decrease the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
stiripentol will reduce the extent or outcome of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Closely. Take into account lowering the dose of CYP2C19 substrates, if adverse reactions are professional when administered concomitantly with stiripentol.
cyclosporine will enhance the stage or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.